Chemotherapy-Induced Leukoencephalopathy: A Case Series

Rationale: Leukoencephalopathy, a complication associated with chemotherapy has been reported after giving high doses of methotrexate and cytarabine no specific risk factors to date. Objectives: To review the prevalence chemotherapy-induced leukoencephalopathy in children acute lymphoblastic leukemia (ALL). present clinical course, pathogenesis neuro-imaging findings ALL. Case: We three cases adolescent ALL precursor B-cell patients who received presented neurologic MRI consistent leukoencephalopathy. Our were only placed on supportive measures adequate hydration, without providing any special intervention. Yet, all them had complete neurological recovery. Discussion Summary: Methotrexate is cell cycle-specific agent that inhibits enzyme dihydrofolate reductase, preventing conversion folic acid tetrahydrofolic inhibiting replication. It one most commonly implicated drug causing leukoencephalopathy.[3] On T2-weighted images, hyperintensities posterior frontal/parietal corona radiata centrum semiovale Complete recovery happened spontaneously cases. There standard treatment for subacute toxicities from methotrexate. Keywords: Chemotherapeutic drugs, Neurotoxicity, Case series